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Thyroid Hormone Conversion Metrics

Meaning

Thyroid Hormone Conversion Metrics are a set of clinical measurements used to evaluate the efficiency and balance of the peripheral conversion of the prohormone Thyroxine (T4) into the biologically active hormone Triiodothyronine (T3), and its inactivation into Reverse T3 (rT3). These metrics provide crucial insight into metabolic health, as T3 is the primary driver of cellular metabolism, energy expenditure, and mitochondrial function. Dysregulation in these conversion pathways often explains symptoms of hypothyroidism despite normal T4 levels. They are vital for assessing true thyroid function.