Thyroid Function Metrics are the specific laboratory assays and clinical parameters used to quantitatively assess the output, utilization, and feedback control of the thyroid gland, primarily involving TSH, Free T4, and Free T3 levels. These metrics provide essential diagnostic data regarding the body’s primary metabolic regulator. Accurate measurement is critical for diagnosing hypo- or hyperthyroidism.
Origin
The term originates from endocrinology, referencing the thyroid gland, and “metrics,” denoting standardized quantitative measurements used for clinical evaluation. These tests have been foundational in thyroidology for decades, reflecting established physiological feedback loops.
Mechanism
The primary mechanism assessed is the Hypothalamic-Pituitary-Thyroid (HPT) axis feedback loop, where TSH acts as the pituitary signal reflecting peripheral tissue demand. Free T3, the biologically active hormone, then dictates basal metabolic rate and energy substrate utilization across nearly all tissues. Monitoring these metrics allows the clinician to discern issues at the gland level versus issues related to hormone conversion or receptor sensitivity peripherally.
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