The clinical strategy of providing comprehensive nutritional, hormonal, or pharmaceutical assistance to optimize the entire Hypothalamic-Pituitary-Thyroid (HPT) axis, ensuring adequate production, conversion, and cellular utilization of thyroid hormones. This support is crucial for maintaining metabolic rate, energy levels, and thermogenesis. It goes beyond simple TSH testing to address peripheral hormone function.
Origin
The term is derived from the HPT axis, the endocrine cascade that regulates thyroid function. ‘Support’ emphasizes a restorative, optimizing approach rather than merely replacing a deficient end product.
Mechanism
Support involves ensuring the hypothalamus correctly releases TRH, the pituitary secretes TSH, and the thyroid gland produces T4 and T3. Crucially, it focuses on peripheral conversion, ensuring the T4 hormone is efficiently converted to the active T3 form in the tissues. Cofactors like selenium and iodine are often provided to support the enzymatic steps of hormone synthesis and conversion, thus maintaining robust thyroid signaling.
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