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Thyroid and Depression

Meaning

Thyroid and Depression describes the clinically significant, bidirectional relationship between the function of the thyroid gland and the manifestation of depressive disorders. Thyroid hormones, specifically T3 and T4, are essential modulators of neurotransmitter activity and overall brain metabolism. Both overt and subclinical hypothyroidism (low thyroid function) are frequently associated with symptoms mirroring major depressive disorder, including fatigue, anhedonia, and cognitive slowing. This connection underscores the need for comprehensive endocrine screening in mental health evaluations.