Thermoregulation Plasticity refers to the adaptive ability of the body’s core temperature control system to adjust its operational set points and response mechanisms in response to chronic or repeated environmental stimuli. This plasticity allows for a more efficient and less metabolically costly maintenance of core temperature across a wider range of external conditions. Enhancing this plasticity is a key strategy for improving metabolic health and energy expenditure.
Origin
The concept combines “thermoregulation,” the physiological process of maintaining core body temperature, and “plasticity,” the biological capacity for change and adaptation. It moves beyond simple homeostasis to describe a system that can be actively trained and modified, particularly through controlled cold and heat exposure.
Mechanism
Plasticity involves structural and functional changes in the hypothalamus, the body’s thermostat, and in peripheral effector tissues. Chronic cold exposure increases brown adipose tissue (BAT) mass and Uncoupling Protein 1 (UCP1) expression, enhancing non-shivering thermogenesis. This adaptive change alters the metabolic landscape, improving insulin sensitivity and contributing to a more robust hormonal response to environmental shifts.
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