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Thermal Signaling

Meaning

This describes the process by which changes in core or peripheral body temperature act as physiological signals, initiating specific cellular and systemic responses beyond simple thermoregulation. Thermal signaling involves the activation of specialized temperature-sensitive receptors and pathways that influence gene expression, metabolic rate, and hormonal release. Clinically, the deliberate use of heat or cold exposure is employed to trigger favorable adaptive responses, such as enhanced mitochondrial function and improved insulin sensitivity. It represents a powerful, non-pharmacological lever for modulating systemic health.