The precise physiological process by which the human body maintains its core internal temperature within a narrow, non-fluctuating range, typically around 37 degrees Celsius, despite wide variations in external environmental temperatures. This complex control is essential for optimal enzyme function, cellular metabolism, and overall survival, representing a critical aspect of autonomic nervous system and endocrine regulation. Impairment of this control is a significant clinical concern, particularly in the elderly.
Origin
This scientific term combines Thermal, relating to heat, with Homeostasis, the state of internal balance, and Control, referring to the regulatory mechanism. It is a fundamental concept in physiology and biophysics.
Mechanism
Control is centrally orchestrated by the hypothalamus, which acts as the body’s thermostat, receiving input from peripheral and central thermoreceptors. Efferent mechanisms include the endocrine system’s modulation of basal metabolic rate via thyroid hormones, the autonomic nervous system’s control of cutaneous blood flow (vasoconstriction/vasodilation), and the sympathetic cholinergic drive of eccrine sweat production. These integrated mechanisms adjust heat production and heat loss to maintain the core set point.
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