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Therapeutic Rationale

Meaning

Therapeutic Rationale is the clear, scientifically grounded justification and logical framework that underpins the selection and application of a specific intervention, whether it be a pharmaceutical agent, a peptide, a nutritional supplement, or a lifestyle modification, within a clinical protocol. A robust rationale connects the observed physiological deficit or desired outcome, supported by diagnostic data, directly to the proposed mechanism of action of the therapeutic agent. This principle ensures that all interventions are evidence-based and purposeful.