What is the Origin of Therapeutic Ketosis?

The concept originated with the clinical use of the ketogenic diet for managing refractory epilepsy, but its application has expanded in functional and anti-aging medicine due to its profound metabolic effects. The term "Therapeutic" emphasizes the controlled, intentional, and health-promoting nature of this metabolic shift.

What is the Mechanism of Therapeutic Ketosis?

The mechanism involves the hepatic breakdown of fatty acids into ketone bodies when carbohydrate intake is severely restricted, leading to a shift in cellular energy substrate preference. Ketone bodies, particularly beta-hydroxybutyrate, are highly efficient fuels for the brain and also act as signaling molecules that can inhibit the inflammatory NLRP3 inflammasome and modify gene expression via histone deacetylase (HDAC) inhibition. This metabolic shift supports hormonal balance by reducing insulin spikes and systemic inflammation.

Therapeutic Ketosis ∞ Area

Therapeutic Ketosis

Meaning

Therapeutic Ketosis is a clinically managed metabolic state achieved through specific dietary or exogenous ketone body interventions, resulting in the liver producing a controlled elevation of ketone bodies (beta-hydroxybutyrate, acetoacetate) as the primary fuel source for the brain and body. This state is utilized in hormonal health to stabilize blood glucose, improve insulin sensitivity, and provide a neuroprotective, anti-inflammatory energy source. It is distinct from pathological ketoacidosis.