What is the Origin of Therapeutic Index?

This concept was pioneered by Alfred J. Clark in the 1920s and is a cornerstone of pharmacology and toxicology, providing a standardized way to assess the safety and efficacy of any therapeutic substance. The term is essential for establishing safe dosing regimens in clinical trials and guiding prescription practices. In hormonal health, it dictates the safe range for hormone replacement and other modulatory agents.

What is the Mechanism of Therapeutic Index?

The index functions as a risk-benefit assessment tool. When a substance has a narrow therapeutic index, slight increases in dosage above the effective level can quickly lead to toxic concentrations, necessitating close clinical monitoring, such as therapeutic drug monitoring. The mechanism guides the clinician to select agents and dosages that maximize the probability of a positive outcome while minimizing the risk of adverse endocrine or systemic effects.

Therapeutic Index

Meaning

The Therapeutic Index, or therapeutic ratio, is a quantitative measurement used in pharmacology and clinical practice to compare the dose of a therapeutic agent that causes a desired clinical effect to the dose that causes toxicity or adverse side effects. It is formally calculated as the ratio of the toxic dose (TD50) to the effective dose (ED50). A high therapeutic index indicates a safer compound, as a wide margin exists between the effective dose and the harmful dose.

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Therapeutic Index

Meaning

Origin

Mechanism

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