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Therapeutic Dosing Cadence

Meaning

Therapeutic Dosing Cadence is the precise, individualized schedule and pattern of administering a therapeutic agent, such as a hormone or peptide, to optimize its physiological efficacy while minimizing potential side effects. This cadence considers the drug’s half-life, the natural diurnal or pulsatile rhythm of the endogenous hormone it mimics, and the patient’s unique pharmacokinetic profile. Moving beyond simple daily dosing, an optimal cadence often involves multiple smaller doses, specific timing relative to the circadian clock, or a pulsatile delivery to replicate youthful physiological signaling. It is the art and science of matching the intervention to the body’s natural kinetics.