Question 1

What is the Meaning of Theranostics?

Accepted Answer

Theranostics refers to a precise medical approach that combines diagnostic imaging with targeted therapeutic intervention. This strategy involves using a single agent or a pair of agents that can both identify and treat a specific disease or biological target within the body.

Question 2

What is the Context of Theranostics?

Accepted Answer

This approach operates within the domain of personalized medicine, primarily in oncology, where it enables clinicians to tailor interventions based on an individual's specific disease characteristics at a molecular level. It applies to various conditions where precise targeting of diseased cells or tissues is beneficial, moving beyond broad systemic treatments.

Question 3

What is the Significance of Theranostics?

Accepted Answer

The practical importance of Theranostics lies in its capacity to enhance treatment efficacy while concurrently minimizing systemic side effects. This integrated method allows for more accurate disease staging, better selection of patients likely to respond to treatment, and real-time monitoring of therapeutic response, thereby improving patient outcomes and overall health.

Question 4

What is the Mechanism of Theranostics?

Accepted Answer

The core mechanism involves utilizing molecular entities designed to bind selectively to disease-specific biomarkers, such as receptors or antigens, expressed on target cells. A diagnostic component, often a radionuclide for imaging, is linked to this targeting molecule to visualize the disease, while a therapeutic component, such as a different radionuclide or drug, is linked to the same or a similar molecule to deliver localized treatment.

Question 5

What is the Application of Theranostics?

Accepted Answer

Clinically, Theranostics is applied in conditions such as metastatic prostate cancer, neuroendocrine tumors, and certain thyroid cancers. Patients first undergo a diagnostic scan to confirm the presence and expression of the specific target. If positive, a therapeutic dose of the targeted agent is administered, often in cycles, to deliver radiation or a therapeutic compound directly to the diseased cells while sparing healthy tissue.

Question 6

What is the Metric of Theranostics?

Accepted Answer

The effects and progression of Theranostics are routinely assessed through post-treatment imaging, typically Positron Emission Tomography (PET) or Single-Photon Emission Computed Tomography (SPECT) scans, to evaluate therapeutic uptake and tumor response. Complementary objective measures include monitoring specific serum tumor markers, alongside ongoing clinical symptom assessment to gauge patient well-being.

Question 7

What is the Risk of Theranostics?

Accepted Answer

Potential risks associated with Theranostics include specific side effects related to the therapeutic agent, such as myelosuppression, kidney dysfunction, or xerostomia, depending on the radiopharmaceutical used. There is also an inherent risk of radiation exposure, and the procedure necessitates specialized infrastructure and expert medical oversight to manage and mitigate these concerns effectively.

Theranostics

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

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