Question 1

What is the Meaning of Theca Cell?

Accepted Answer

Theca cells are specialized endocrine cells located within the ovarian follicle, positioned external to the granulosa cell layer. Their primary physiological role involves the synthesis of androgen precursors, specifically androstenedione and testosterone, which are essential for subsequent estrogen production in the ovary.

Question 2

What is the Context of Theca Cell?

Accepted Answer

These cells operate as a critical component of the ovarian follicular unit, participating in the intricate process of steroidogenesis. Within the two-cell, two-gonadotropin model, theca cells collaborate with granulosa cells to facilitate the maturation of the follicle and the eventual release of an oocyte, thereby supporting reproductive function.

Question 3

What is the Significance of Theca Cell?

Accepted Answer

The proper function of theca cells is paramount for maintaining female reproductive health and hormonal balance. Their activity directly impacts the regulation of the menstrual cycle and fertility, and dysregulation of these cells is frequently implicated in conditions such as Polycystic Ovary Syndrome, affecting numerous individuals.

Question 4

What is the Mechanism of Theca Cell?

Accepted Answer

Upon stimulation by luteinizing hormone (LH) secreted from the pituitary gland, theca cells convert cholesterol into androstenedione and testosterone. These androgenic compounds then diffuse across the basement membrane into the adjacent granulosa cells, where the enzyme aromatase converts them into estrogens.

Question 5

What is the Application of Theca Cell?

Accepted Answer

Understanding the role of theca cells is fundamental in clinical endocrinology, guiding the diagnosis and management of various hormonal disorders. Clinicians consider the implications of altered theca cell function when addressing issues related to androgen excess, menstrual irregularities, or infertility in patients.

Question 6

What is the Metric of Theca Cell?

Accepted Answer

The functional status of theca cells is not directly measured but is indirectly assessed through the evaluation of circulating androgen levels. Serum biomarkers such as total testosterone, free testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEA-S) provide valuable insights into potential abnormalities in theca cell activity.

Question 7

What is the Risk of Theca Cell?

Accepted Answer

Aberrant or excessive activity of theca cells can lead to hyperandrogenism, a condition characterized by elevated androgen levels. This hormonal imbalance may manifest clinically as hirsutism, acne, and oligo-amenorrhea, and is a hallmark feature of Polycystic Ovary Syndrome, carrying implications for metabolic health and reproductive outcomes.

Theca Cell

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

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