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The KEEPS Study

Meaning

An acronym for the Kronos Early Estrogen Prevention Study, a large-scale, multi-center, randomized, placebo-controlled clinical trial designed to rigorously evaluate the effects of hormone therapy initiated early in the postmenopausal period on the progression of subclinical atherosclerosis and various other health outcomes. This landmark study provided essential, high-quality data on the cardiovascular, bone, and cognitive effects of different hormone regimens in women who were recently menopausal. It is a key reference in the contemporary clinical discussion regarding the “timing hypothesis” for menopausal hormone therapy.