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Tfeb Pathway Activation

Meaning

Tfeb Pathway Activation refers to the intentional stimulation of the Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, the cellular process of recycling damaged components. Clinically, activating TFEB is a powerful strategy in longevity medicine to enhance cellular housekeeping, clear aggregated proteins, and improve mitochondrial quality control. This targeted activation is crucial for maintaining cellular health, particularly in post-mitotic tissues like muscle and neurons, which are prone to accumulating cellular debris over time.