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Testosterone Withdrawal Symptoms

Meaning

Testosterone Withdrawal Symptoms are the constellation of adverse physiological and psychological manifestations that occur when exogenous testosterone therapy is abruptly discontinued or when the dose is rapidly reduced, leading to a state of acute or severe hypogonadism. Common clinical presentations include profound fatigue, loss of libido, depressive mood, muscle mass atrophy, and significant reductions in energy and motivation. These symptoms are a direct consequence of the suppressed endogenous testosterone production that often accompanies long-term exogenous administration. Clinical management requires a carefully titrated exit strategy to allow the hypothalamic-pituitary-testicular (HPT) axis to recover.