Skip to main content

Testosterone Trials

Meaning

Testosterone Trials refers collectively to a series of large-scale, methodologically rigorous, randomized, placebo-controlled clinical studies designed to systematically evaluate the clinical efficacy and long-term safety of testosterone replacement therapy (TRT) in men with documented low testosterone levels. These investigations, such as the seminal NIH-funded Testosterone Trials, aim to move the clinical practice of male hormonal health from empirical treatment to an evidence-based model. They provide the critical data necessary to establish standardized, evidence-based guidelines for the appropriate use of TRT.