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Testosterone Signaling Integrity

Meaning

Testosterone Signaling Integrity describes the optimal functional status of the entire biological pathway by which the testosterone molecule exerts its effects on target cells and tissues. This integrity encompasses the hormone’s free circulation, its successful binding to the androgen receptor, and the subsequent activation of intracellular genomic and non-genomic cascades. Compromised integrity, often due to receptor downregulation or increased Sex Hormone Binding Globulin (SHBG), can lead to symptoms of deficiency even with normal total testosterone levels. Maintaining this integrity is crucial for muscle mass, bone density, and neurological health.