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Testosterone Rhythm Management

Meaning

The clinical practice of regulating and optimizing the natural, time-dependent fluctuations in testosterone concentration, which typically peak in the early morning and reach their nadir in the evening. This management strategy aims to preserve or restore the physiological pulsatility and diurnal variation of testosterone, particularly when administering exogenous therapy, to maximize efficacy and minimize disruption to the body’s endogenous hormonal feedback loops.