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Testosterone Rhythm

Meaning

The predictable, cyclical variation in the concentration of circulating testosterone over a 24-hour period, a phenomenon known as a diurnal or circadian rhythm. In healthy males, this pattern is characterized by peak serum levels occurring in the early morning, typically coinciding with or shortly after waking, followed by a gradual decline throughout the day to a nadir in the evening. This rhythm is a key indicator of the functional integrity of the hypothalamic-pituitary-gonadal (HPG) axis.