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Testosterone Replacement Therapy Stress

Meaning

Testosterone Replacement Therapy Stress is a clinical concept describing the transient or chronic physiological burden placed on the endocrine system and other organ systems when exogenous testosterone is introduced, particularly when the therapy is improperly dosed, timed, or monitored. This stress can manifest as suppression of the natural Hypothalamic-Pituitary-Gonadal (HPG) axis, adverse changes in hematocrit, or undesirable shifts in estrogen metabolism. It underscores the necessity of precise, individualized clinical management.