The observed improvements in cognitive domains, such as executive function, spatial memory, and mood regulation, documented following the achievement of eugonadal testosterone levels in deficient men.
Origin
These benefits are recognized as secondary outcomes of testosterone replacement therapy (TRT), moving the clinical focus beyond just physical symptoms to neurocognitive health.
Mechanism
Testosterone, acting via androgen receptors in the brain, modulates neurotransmitter systems, supports neurogenesis, and reduces cerebral inflammation, contributing to enhanced synaptic plasticity and function.
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