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Testosterone Replacement Cessation

Meaning

Testosterone Replacement Cessation describes the clinical process of deliberately discontinuing exogenous testosterone therapy, which may be initiated voluntarily by the patient or necessitated by a medical indication. This cessation inevitably leads to a rapid decline in circulating testosterone levels, potentially resulting in a temporary or sometimes prolonged state of clinical hypogonadism and a recurrence of associated symptoms such as profound fatigue, significant mood lability, and the loss of accrued lean mass. The clinical management of this post-cessation period requires careful endocrine monitoring and structured supportive care.