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Testosterone Regulation

Meaning

The intricate homeostatic control system that governs the synthesis, secretion, transport, and metabolic breakdown of the androgen hormone testosterone within the body. This process is tightly controlled by the Hypothalamic-Pituitary-Gonadal (HPG) axis through a negative feedback loop. Proper testosterone regulation is essential for maintaining muscle mass, bone density, libido, erythropoiesis, and overall metabolic health in both sexes. Disruptions in this regulatory axis can lead to clinical conditions like hypogonadism or hyperandrogenism.