What is the Origin of Testosterone Influence on Cognition?

This concept stems from neuroendocrinology research, which established the presence of androgen receptors in key brain regions like the hippocampus and prefrontal cortex. Clinical observations of cognitive changes in individuals with androgen deficiency further solidified this link.

What is the Mechanism of Testosterone Influence on Cognition?

Testosterone exerts its influence by binding to androgen receptors directly or by being converted to estradiol via aromatase, which then acts on estrogen receptors in the brain. These hormonal signals modulate neurotransmitter release and receptor density, and they promote neurogenesis and synaptogenesis. Optimal testosterone levels are essential for maintaining the structural integrity and metabolic health of neurons, thereby supporting long-term cognitive function.

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Testosterone Influence on Cognition

Meaning

Testosterone influence on cognition describes the direct and indirect modulatory effects of the primary male androgen on various executive functions, spatial abilities, memory, and mood in both men and women. Testosterone acts as a neurosteroid, influencing neuronal structure and function, which is critical for maintaining cognitive vitality and preventing age-related decline. The hormone’s effect is particularly pronounced in areas of the brain associated with spatial memory and attention.