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Testosterone Gene Expression

Meaning

Testosterone gene expression refers to the molecular process by which the presence of testosterone, or its potent metabolite dihydrotestosterone (DHT), influences the transcription of specific genes within target cells. This action is mediated by the intracellular androgen receptor (AR), which, upon binding the hormone, translocates to the nucleus and modulates DNA transcription. The resulting change in protein synthesis drives the hormone’s profound effects on muscle growth, bone density, and the maintenance of male secondary characteristics.