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Testosterone Disruption

Meaning

Testosterone Disruption is defined as any process or factor that interferes with the normal synthesis, systemic transport, metabolic breakdown, or cellular action of the androgen hormone testosterone within the body. This disruption can be caused by various internal factors, such as genetic enzyme polymorphisms or chronic HPA axis stress, or by external factors, including exposure to endocrine-disrupting chemicals. The clinical outcome is a suboptimal or pathological testosterone status, which profoundly affects physical and mental health in all genders. Identifying the precise source of disruption is the critical first step for effective hormonal restoration.