Testosterone cycling is a protocol in which exogenous testosterone or testosterone-stimulating agents are administered for a defined period, followed by a period of cessation or reduced dosage. This approach is often employed in non-clinical settings to maximize anabolic effects while attempting to mitigate long-term side effects or dependence. In clinical endocrinology, the practice is typically discouraged due to the risks associated with abrupt hormonal fluctuations.
Origin
The concept originated largely within the bodybuilding and performance-enhancement communities as a method to exploit the benefits of high testosterone levels while theoretically allowing the hypothalamic-pituitary-gonadal axis to recover during “off” periods. It is not a standard, evidence-based clinical practice for treating hypogonadism.
Mechanism
During the “on” phase, supraphysiological testosterone levels drive protein synthesis and muscle hypertrophy by activating androgen receptors. The subsequent “off” phase is intended to allow the body’s natural testosterone production to resume, which is suppressed by the exogenous hormone via negative feedback on the pituitary and hypothalamus. However, this recovery is often incomplete, leading to prolonged hypogonadism and systemic instability.
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