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Testosterone Cessation

Meaning

Testosterone Cessation refers to the clinical process of discontinuing exogenous Testosterone Replacement Therapy (TRT) in a patient who has been receiving treatment for hypogonadism or other indications. This action is often undertaken due to patient preference, the emergence of adverse side effects, or a change in clinical goals. Following cessation, patients typically experience a transient period of hypogonadal symptoms as the suppressed Hypothalamic-Pituitary-Gonadal (HPG) axis slowly attempts to restore endogenous testosterone production. Clinical management during this period often involves supportive care and, occasionally, the use of agents like selective estrogen receptor modulators to facilitate the recovery of testicular function.