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Testosterone Bioavailability

Meaning

Testosterone bioavailability refers to the fraction of total circulating testosterone that is biologically active and available to interact with androgen receptors in target tissues, primarily defined by the amount of free, unbound hormone. This crucial metric is determined by the route of administration, the specific pharmaceutical preparation used, and, most importantly, the concentration of Sex Hormone-Binding Globulin (SHBG) in the blood. Optimizing bioavailability, rather than just total levels, is the key clinical objective for effective Testosterone Replacement Therapy (TRT).