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Testosterone and Mood

Meaning

Testosterone and Mood describes the clinically significant, complex, and bidirectional relationship between circulating levels of the primary male androgen and the regulation of affective state, emotional resilience, and overall psychological well-being. Optimal testosterone levels are frequently correlated with improved energy, motivation, and a reduction in symptoms of irritability and mild depression in both men and women. Conversely, clinically significant hypogonadism is often associated with symptoms such as apathy, dysphoria, and decreased sense of vitality, highlighting the hormone’s profound neuroendocrine influence. The interplay is modulated by the conversion of testosterone to estradiol and its direct action on various brain regions.