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Testosterone and Immunity

Meaning

Testosterone and Immunity describes the complex, bidirectional relationship between the primary male sex hormone, testosterone, and the various components of the innate and adaptive immune system. Testosterone generally exhibits an overall immunosuppressive or anti-inflammatory effect, which partially explains the observed sex differences in immune response and susceptibility to certain autoimmune conditions. Maintaining testosterone within its healthy physiological reference range is crucial, as both frank deficiency and pathological excess can negatively impact immune surveillance and inflammatory balance. This hormonal-immune crosstalk is a vital aspect of health, disease pathology, and longevity.