What is the Origin of Testosterone and Dry Eye?

The understanding of this relationship originated from research in ocular endocrinology, which identified high-affinity androgen receptors on the meibomian and lacrimal glands. Clinical observations of higher DED prevalence in women, especially following a sharp decline in androgens after menopause or oophorectomy, further established this hormonal link.

What is the Mechanism of Testosterone and Dry Eye?

Testosterone acts as a critical trophic and anti-inflammatory factor on the meibomian glands, stimulating the production and secretion of the tear film's lipid layer, which prevents rapid tear evaporation. Androgens also regulate the function of the lacrimal glands, influencing the aqueous component of the tear film. A deficiency in testosterone or a high estrogen-to-testosterone ratio can lead to meibomian gland dysfunction and inflammation, directly causing tear film instability and dry eye symptoms.

Testosterone and Dry Eye ∞ Area

Testosterone and Dry Eye

Meaning

Testosterone and Dry Eye describes the established clinical and physiological link between systemic androgen deficiency or imbalance and the development or exacerbation of dry eye disease (DED), particularly the evaporative subtype. This connection is highly relevant to women post-menopause and individuals with certain endocrine disorders. Optimal testosterone levels are integral to maintaining a healthy ocular surface ecosystem.