What is the Origin of Testosteron Replacement Therapy?

TRT originated in the mid-20th century as a treatment for primary and secondary hypogonadism identified through clinical presentation and low serum testosterone measurements. The term replacement signifies restoring a deficient endogenous substance.

What is the Mechanism of Testosteron Replacement Therapy?

Exogenous testosterone binds to androgen receptors throughout the body, activating genomic and non-genomic signaling pathways that promote anabolism, erythropoiesis, and libido restoration. A critical mechanistic consideration is the subsequent negative feedback loop that suppresses the HPG axis, requiring careful dosing protocols to balance symptom relief with pituitary function preservation.

Testosteron Replacement Therapy

Meaning

The medical administration of exogenous testosterone or its derivatives to correct clinical hypogonadism, restoring circulating levels to a predefined, therapeutically effective range. This therapy directly addresses symptoms arising from insufficient endogenous androgen production. It is a clinical intervention requiring careful endocrinological oversight.