What is the Meaning of Tesamorelin?

Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) used specifically to reduce excess visceral adipose tissue in adults with HIV-associated lipodystrophy. While not a primary longevity compound, its utility lies in its targeted action on fat distribution, which has significant downstream implications for metabolic and hormonal health. It acts as a powerful modulator of the somatotropic axis.

What is the Origin of Tesamorelin?

The name Tesamorelin is a pharmaceutical designation assigned to this specific peptide structure, reflecting its development history and its intended function as a GHRH analogue. It is a modern pharmacological nomenclature.

What is the Mechanism of Tesamorelin?

This compound selectively stimulates the pituitary gland to release endogenous growth hormone (GH) in a pulsatile manner, mimicking the body's natural pattern. Increased GH signaling promotes lipolysis, particularly targeting visceral fat depots which are metabolically detrimental. By reducing visceral adiposity, Tesamorelin indirectly improves insulin sensitivity and reduces the inflammatory signaling associated with excess abdominal fat, thus supporting better overall metabolic function.

Tesamorelin ∞ Area ∞ Library 97

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