The Tesamorelin Protocol refers to the clinical administration of Tesamorelin, a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH), designed to stimulate the pituitary gland’s natural, pulsatile release of endogenous Human Growth Hormone (HGH). This protocol is specifically utilized to reduce pathological visceral adipose tissue and improve body composition in appropriate clinical settings. It represents a precise, targeted pharmacological strategy for HGH optimization and body composition management.
Origin
Tesamorelin was developed in the early 2000s and received regulatory approval for treating HIV-associated lipodystrophy, a condition characterized by excessive and dangerous visceral fat accumulation. The protocol’s use in the broader wellness space is an off-label application, leveraging its potent and highly targeted effect on central abdominal fat reduction for metabolic benefit.
Mechanism
As a GHRH analog, Tesamorelin binds specifically to the GHRH receptors on somatotroph cells in the anterior pituitary gland, thereby increasing the production and physiological release of HGH in a pulsatile manner. This increase in HGH then leads to a subsequent, sustained rise in Insulin-like Growth Factor 1 (IGF-1) from the liver, which mediates the powerful lipolytic effect, specifically targeting and reducing visceral fat stores without significantly altering the subcutaneous fat compartment.
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