Tesamorelin Metabolic Function refers to the specific physiological effects mediated by the synthetic peptide Tesamorelin, a growth hormone-releasing factor (GRF) analog, particularly its role in improving body composition and metabolic parameters. Clinically, it is known for its ability to selectively reduce visceral adipose tissue (VAT) in specific populations, which is metabolically harmful fat stored deep within the abdominal cavity. Beyond VAT reduction, it promotes lipolysis and influences the overall lipid and glucose metabolism, contributing to a healthier metabolic profile. This function is achieved by stimulating the pituitary gland.
Origin
Tesamorelin was developed as a therapeutic agent based on the structure of the naturally occurring hypothalamic hormone, growth hormone-releasing hormone (GHRH). The term ‘metabolic function’ specifies its primary therapeutic utility beyond simple growth promotion. Its clinical use was pioneered in populations with specific metabolic disturbances, such as HIV-associated lipodystrophy.
Mechanism
Tesamorelin functions by binding to and activating the GHRH receptors on the anterior pituitary gland. This binding stimulates the pulsatile, endogenous release of growth hormone (GH) from the pituitary. The subsequent increase in GH levels then acts on target tissues, including the liver, to increase IGF-1 production, which in turn promotes lipolysis and the reduction of visceral fat mass. This mechanism is distinct from direct GH administration, offering a more physiological pattern of release.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.