What is the Origin of Tesamorelin Mechanism?

Tesamorelin was developed as a targeted pharmacological agent based on the structure and function of the naturally occurring hypothalamic GHRH. Its mechanism represents a nuanced approach to modulating the somatotropic axis.

What is the Mechanism of Tesamorelin Mechanism?

The drug mimics the physiological GHRH signal, prompting the pituitary to release its stored GH in a more natural, pulsatile manner, which is thought to reduce the potential for adverse effects associated with continuous exogenous GH administration. This enhanced GH secretion leads to increased hepatic production of IGF-1, which mediates many of the growth-promoting and metabolic effects, including lipolysis and protein synthesis, while maintaining the integrity of the negative feedback loop.

Tesamorelin Mechanism ∞ Area

Tesamorelin Mechanism

Meaning

The specific pharmacological action of Tesamorelin, a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH), which selectively binds to GHRH receptors in the anterior pituitary gland. This binding stimulates the endogenous, pulsatile secretion and synthesis of growth hormone (GH), thereby increasing circulating levels of Insulin-like Growth Factor 1 (IGF-1) without directly administering exogenous GH. It is primarily used to reduce excess visceral adipose tissue in specific clinical populations.