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Term 11

Meaning

Term 11 represents a quantifiable assessment of target tissue sensitivity to endogenous or exogenous glucocorticoid signaling within the context of HPA axis regulation. This index aids clinicians in discerning whether altered cortisol effects stem from primary adrenal dysfunction or peripheral tissue resistance mechanisms. Understanding this metric is crucial for optimizing replacement therapy and managing inflammatory states effectively. Accurate measurement informs differential diagnosis between Cushing’s syndrome variants and relative adrenal insufficiency presentations. The value correlates inversely with systemic tissue downregulation observed during chronic hypercortisolemia.