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Tenocytes

Meaning

Tenocytes are the specialized, elongated, spindle-shaped fibroblast-like cells that represent the principal cellular component of tendons and ligaments, essential for maintaining the mechanical and structural integrity of these connective tissues. These cells are embedded within the extracellular matrix, where their primary function is the continuous synthesis and organization of the collagen fibers, predominantly Type I collagen, and other matrix components. Tenocytes are fundamentally crucial for the tissue’s adaptive response to mechanical loading, its ability to repair following injury, and the overall health of the musculoskeletal system. Their activity is dynamically modulated by local and systemic hormonal signals.