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Ten-Eleven Translocation (TET) Enzymes

Meaning

Ten-Eleven Translocation (TET) Enzymes are a family of three dioxygenase enzymes (TET1, TET2, and TET3) that play a critical, active role in DNA demethylation by catalyzing the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives. These enzymes are central to the dynamic and reversible regulation of gene expression, linking environmental and metabolic signals to the long-term programming of the genome. They are essential for epigenetic plasticity.