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Ten-Eleven Translocation Enzymes

Meaning

Ten-Eleven Translocation Enzymes, commonly known as TET enzymes, are a family of iron- and alpha-ketoglutarate-dependent dioxygenase enzymes that catalyze the oxidation of 5-methylcytosine (5mC) in DNA. These enzymes play a fundamental and crucial role in the active DNA demethylation pathway, a process essential for regulating gene expression and maintaining cellular identity. They are key players in the dynamic field of epigenetics.