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Temporal Pharmacology Principles

Meaning

The application of chronobiology concepts to the field of pharmacology, specifically focusing on how the timing of drug administration influences the absorption, distribution, metabolism, and excretion (ADME) kinetics and the overall therapeutic effect of a substance. These principles acknowledge that the body’s physiological functions, including enzyme activity, receptor density, and hormone secretion, exhibit predictable 24-hour rhythms, making the time of dosing a critical determinant of clinical outcome.