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Temporal Integration Strategy

Meaning

Temporal Integration Strategy is a sophisticated clinical approach that involves synchronizing the administration of therapeutic agents, particularly hormones and peptides, with the body’s natural circadian, ultradian, and infradian biological rhythms. This strategy aims to mimic the native, pulsatile, and cyclical secretion patterns of the endocrine system to maximize receptor sensitivity, optimize biological signaling fidelity, and reduce the risk of receptor downregulation or desensitization. It is the art and science of dosing according to the biological clock.