Telomere Support Science is the field dedicated to developing and implementing interventions that preserve or restore the length and structural integrity of telomeres, the protective caps on the ends of chromosomes. Telomere shortening is a well-established biomarker of cellular aging and is associated with reduced cellular replication capacity and increased disease risk. Clinical support protocols aim to slow this attrition to extend cellular healthspan.
Origin
This field is founded upon decades of molecular biology research that identified telomeres and the enzyme telomerase, culminating in a Nobel Prize in 2009. The clinical application emerged as telomere length measurement became a viable biomarker for biological age and longevity potential. It provides a tangible, measurable target for anti-aging and regenerative medicine strategies.
Mechanism
The primary mechanism of support involves activating the telomerase enzyme, a reverse transcriptase that adds repetitive DNA sequences to the telomere ends, thereby counteracting the shortening that occurs with each cell division. Additionally, support strategies focus on reducing the oxidative stress and inflammation that accelerate telomere attrition by damaging the DNA. Targeted compounds and lifestyle factors can modulate these pathways, helping to maintain the protective cap and preserve genomic stability.
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