Telomere Support Mechanisms are the specific physiological levers that mitigate the rate of telomere shortening, thereby promoting cellular longevity and sustained function. These mechanisms often involve optimizing the internal milieu to reduce cellular stress and enhance repair capacity. Supporting these functions is central to managing biological age.
Origin
This term arises from the convergence of aging research and endocrinology, recognizing that systemic hormonal balance directly impacts cellular aging biomarkers. It focuses on proactive strategies rather than passive observation.
Mechanism
Key support mechanisms include the careful management of the chronic stress response, as high cortisol accelerates telomere attrition, and optimizing the availability of essential nutrients that act as cofactors for DNA repair enzymes. Furthermore, interventions that boost mitochondrial efficiency reduce the production of damaging reactive oxygen species that physically erode telomeric DNA.
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