Telomere Maintenance Science is the field dedicated to understanding the enzymatic and regulatory mechanisms that preserve the length and integrity of telomeres, the protective caps at the ends of chromosomes. Successful maintenance is intrinsically linked to cellular longevity and the prevention of replicative senescence, a key aspect of hormonal aging research. Optimal maintenance is crucial for genomic stability.
Origin
This area of study originates from molecular genetics, specifically the discovery of telomeres and the telomerase enzyme responsible for their maintenance. The science focuses on the interplay between telomere attrition and the endocrine environment.
Mechanism
The primary mechanism involves the enzyme telomerase, which synthesizes new telomeric repeats, counteracting the shortening that occurs during normal cell division. Factors such as oxidative stress, chronic inflammation (SASP), and hormonal milieu influence telomerase activity and subsequent telomere length. Understanding how hormones modulate this enzyme is a current focus in longevity and anti-aging endocrinology.
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