The process of increasing the activity or expression of the enzyme telomerase, which is responsible for maintaining the length of telomeres at the ends of chromosomes, thereby potentially slowing cellular replicative senescence. In a wellness context, this relates to strategies aimed at preserving cellular lifespan potential.
Origin
This concept is derived directly from molecular gerontology, where telomere attrition is a recognized biomarker of cellular aging. Upregulation refers to boosting the activity of this critical protective enzyme.
Mechanism
While complex, certain lifestyle factors and targeted nutritional compounds are hypothesized to modulate the expression of the TERT gene, which codes for the catalytic subunit of telomerase. By stabilizing telomere length, the cell retains its proliferative capacity and avoids entering senescence, which indirectly supports robust endocrine gland function over time.
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