What is the Origin of Telomerase Activity Modulation?

This term is a key concept in molecular biology, gerontology, and longevity research, following the Nobel Prize-winning work on telomeres and telomerase. "Telomerase Activity" refers to the enzyme's function, and "Modulation" signifies the precise, controlled adjustment of this function. It represents a direct molecular approach to managing the cellular clock of aging.

What is the Mechanism of Telomerase Activity Modulation?

Telomerase, composed of a catalytic protein subunit (TERT) and an RNA template (TERC), functions by using its RNA template to synthesize new DNA repeats onto the

Telomerase Activity Modulation

Meaning

Telomerase Activity Modulation describes the therapeutic strategy of intentionally regulating the activity of the telomerase enzyme, a reverse transcriptase that adds repetitive nucleotide sequences (telomeres) to the ends of chromosomes. While excessive telomerase activity is linked to oncogenesis, a controlled, temporary increase can counteract the progressive shortening of telomeres associated with cellular aging and senescence. The goal of modulation is to maintain telomere length sufficient to preserve genomic stability and extend the replicative capacity of healthy cells, thereby promoting longevity.