What is the Origin of TCF7L2?

The gene was identified as a critical metabolic risk factor through large-scale Genome-Wide Association Studies (GWAS) that scanned the human genome for common genetic variations linked to disease. Its name is derived from its function as a transcription factor in the T-cell factor/lymphoid enhancer factor (TCF/LEF) family, reflecting its role in gene regulation.

What is the Mechanism of TCF7L2?

The TCF7L2 protein acts as an effector in the canonical Wnt signaling cascade, which plays a role in the growth and function of the insulin-producing beta cells in the pancreas. Risk-associated variants of the gene are hypothesized to impair the gene's ability to regulate the expression of key genes involved in glucose-stimulated insulin secretion and proinsulin processing. This disruption leads to a failure of the beta cells to adequately compensate for peripheral insulin resistance, thus precipitating T2DM.

TCF7L2

Meaning

TCF7L2, or Transcription Factor 7-Like 2, is a gene that encodes a nuclear protein functioning as a key transcription factor within the Wnt signaling pathway, which is essential for numerous developmental processes. This specific gene is recognized as the single most strongly associated genetic risk factor for the development of Type 2 Diabetes Mellitus (T2DM) across various populations. Variations in TCF7L2 are thought to directly impair the function of pancreatic beta-cells, leading to deficient insulin secretion.

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TCF7L2

Meaning

Origin

Mechanism

Can Genetic Predispositions to Metabolic Conditions Impact Wellness Program Access?

Could My Genetic Information from a Company Wellness Program Affect My Life Insurance Rates?

What Are the Long-Term Implications of Genetic Influences on Metabolic Health?

Can Genetic Predispositions Alter Metabolic Treatment Efficacy?

How Do Genetic Factors Influence Dietary Responses in PCOS?

Are There Specific Genetic Markers That Predict Response to Lifestyle Interventions for Insulin Resistance?

How Do Genetic Variations Affect Fasting Glucose Regulation?

How Do Individual Genetic Variations Influence Hormonal Responses to Insulin?

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